New method for synthesizing dialdehyde compound

一种新的合成二醛化合物的方法

Abstract

The invention provides a method for synthesizing a dialdehyde compound, and an acetal represented by the structural formula (I) and a Grignard reagent represented by the structural formula (II) are subjected to a coupling reaction and then hydrolyzed to obtain the dialdehyde compound, wherein the structural formula (I) and the structural formula (II) are described in the specification. The method has the advantages of high reaction activity, the reaction can be carried out even under the condition of room temperature, the reaction completed time is short, almost no other by-products are generated, no catalyst is required to be used, the reaction yield is high, and the reaction speed is fast. Moreover, the product purity is high, the dialdehyde compound with the purity of about 98% can be obtained after concentration, and no complex purification process is required.
本发明提供了一种合成二醛化合物的方法,结构式(I)所示缩醛与结构式(II)所示格氏试剂偶联反应后水解得到:本发明方法反应活性高,甚至在室温条件下即可进行反应,反应完成时间短,几乎无其他副产物生成,无需催化剂的使用,反应产率高、速度快。而且产品纯度高,浓缩后即可获得纯度为98%左右的二醛类化合物,不需要复杂的提纯过程。

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Patent Citations (1)

    Publication numberPublication dateAssigneeTitle
    JP-S5695142-AAugust 01, 1981T Hasegawa Co LtdPreparation of aliphatic aldehyde

NO-Patent Citations (1)

    Title
    朱卓越等: "3-溴-1,6-萘啶-5(6H)-酮的合成", 《华中师范大学学报(自然科学版)》

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