4-phenyl-2-aminopyrimidine compound, as well as preparation method and applications thereof

4-苯基-2-氨基嘧啶类化合物及其制备方法与应用

Abstract

本发明公开了一种4-苯基-2-氨基嘧啶类化合物,其结构如通式I所示:其中,X为或R0为氢、甲基或乙基;R1为氢、甲基、乙基或异丙基;R2为异丙基、甲硫甲基、取代苯基或吲哚基;化合物为R构型、S构型或消旋体。本发明的化合物结构新颖,以4-苯基-2-氨基嘧啶作为新型母核,并在苯基的间位或对位引入不同类型的氨基酸,得到了具有抑制肿瘤细胞(PC-3)生长活性的结构全新的化合物。
The invention discloses a 4-phenyl-2-aminopyrimidine compound, the structure of which is shown in the general formula I, wherein X is shown in the specification, R0 is hydrogen, methyl or ethyl; R1 is hydrogen, methyl, ethyl or isopropyl; R2 is isopropyl, methylthio methyl, substituted phenyl or indolyl; the compound is R configuration, S configuration or racemate. The compound is novel in structure, and the compound with a brand-new structure and the capability of inhibiting the growth activity of tumor cells (PC-3) can be obtained by taking 4-phenyl-2-aminopyrimidine as a novel parent nucleus and introducing different types of amino acids into meta-position or para-position of phenyl.

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Cited By (1)

    Publication numberPublication dateAssigneeTitle
    CN-106045918-AOctober 26, 2016山东大学具有Akt抑制活性的取代嘧啶类衍生物及其制备方法与应用