生物相容性医用高分子超声成像微球

Biologically-compatible medical high-molecular ultrasonic imaging microballoon

Abstract

本发明公开了一种生物相容性医用高分子超声成像微球。该微球为中空型无机/有机/无机三层结构,位于微球中心的是空腔,内部填充空气;空腔外层为Fe3O4磁性粒子;中间层为聚丙烯酰胺-聚甲基丙烯酸无规共聚物与聚甲基丙烯酸、二乙烯基苯通过自由基共聚得到的核/壳聚合物纳米微球,共聚物与内层Fe3O4磁性粒子之间通过内表面羧基与铁盐可形成配位键或离子键而稳定;外层为二氧化硅,通过微球的表面的羧基与二氧化硅表面的硅羟基产生氢键作用而连接。该材料优点是:聚合物微球属于纳米级粒子;内层Fe3O4磁性粒子使造影剂可靶向定位;二氧化硅空心微球具有很好的生物相容性和机械稳定性,内部空腔在造影模式下可以产生强的回波信号。
The invention discloses a biologically-compatible medical high-molecular ultrasonic imaging microballoon. The microballoon has a hollow type inorganic/organic/inorganic three-layer structure, a cavity is disposed at the center of the microballoon, and the interior is filled with air; the outer layer of the cavity is a Fe3O4 magnetic particle; the middle layer is a core/shell polymer nanosphere obtained through free radical copolymerization of a polyacrylamide-polymethacrylic acid random copolymer and polymethacrylic acid and divinyl benzene, and stabilization is realized due to the fact that the copolymer and the inner-layer Fe3O4 magnetic particle can form a coordination bond or an ionic bond through inner-surface carboxyl and a ferric salt; and the outer layer is silicon dioxide, and connection is realized due to the fact that carboxyl on the surface of the nanosphere and silanol on the surface of silicon dioxide have hydrogen-bond interaction. The material has the advantages that the polymer microballoon belongs to a nanometer level particle; the inner-layer Fe3O4 magnetic particle enables a prepared contrast agent to realize targeted positioning; the silicon dioxide hollow microballoon has extremely good biocompatibility and mechanical stability, and the internal cavity can generate strong echo signals under a contrast mode.

Claims

Description

Topics

Download Full PDF Version (Non-Commercial Use)

Patent Citations (0)

    Publication numberPublication dateAssigneeTitle

NO-Patent Citations (2)

    Title
    K. ZHANG 等: "Magnetic polymer enhanced hybrid capsules prepared from a novel Pickering emulsion polymerization and their application in controlled drug release", 《COLLOIDS AND SURFACES A: PHYSICOCHEMICAL AND ENGINEERING ASPECTS》
    NAM SEON KIM 等: "Core-shell polymerization for monodispersed hollow polymer spheres embedded with magnetic nanoparticles", 《JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY》

Cited By (0)

    Publication numberPublication dateAssigneeTitle