Method and system for acquiring age of female individual of Chinese population

一种获得中国人群女性个体年龄的方法和系统

Abstract

本发明提供一种获得中国人群女性个体年龄的方法和系统,所述方法包括提取所述女性个体的DNA;获得所述DNA的11个CpG位点的甲基化率;将所述各CpG位点的甲基化率,采用SPSS17软件,对11个CpG位点与年龄进行回归分析,构建回归模型,以获得所述中国人群女性个体年龄。本发明提供的方案能准确地获得中国人群女性个体的年龄,可以利用公安实战中犯罪现场遗留的生物检材血液或血痕样本,进行个体年龄的推断,将有利于快速锁定嫌疑人范围,为案件侦破提供线索,提高案件侦破速度。
The invention provides a method and a system for acquiring an age of a female individual of Chinese population. The method comprises the following steps: extracting DNA (Deoxyribonucleic Acid) of the female individual, acquiring methylation indexes of 11 CpG loci of the DNA, conducting regress analysis to the methylation indexes of each GpG loci, the 11 CpG loci and the age with SPSS 17 (Statistic Package for Social Science) software, and constructing a regression model to obtain the age of the female individual of the Chinese population. The scheme provided by the invention can accurately obtain the age of the female individual of the Chinese population, deduces the age of the individual with a biologically examined blood or blood stain sample remained in a crime scene of the public security actual combat, so as to facilitate targeting of the range of criminal suspects, provide clues for investigation of the case, and increase the detection speed of the case.

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    SHAO HUA YI,ET AL: "Isolation and identification of age-related DNA methylation markers for forensic age-prediction", 《FORENSIC SCIENCE INTERNATIONAL: GENETICS》, vol. 11, 31 July 2014 (2014-07-31), pages 117 - 125
    VARDHMAN K. RAKYAN,ET AL: "Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains", 《GENOME RESEARCH》, 10 March 2010 (2010-03-10), pages 434 - 439

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